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The final analysis included 2 069 785 children. We identified all singleton live births from 1 January 1978 to 31 December 2012 ( n = 2 105 712) from the Danish Medical Birth Registry (Bliddal et al., 2018) and excluded 461 children who had missing or extreme gestational age (315 days), 86 children without information on sex, 28 611 children with chromosomal abnormalities and 6769 children without links to their fathers. In Denmark, all live births have a unique personal identification number that permits an accurate linkage of individual-level data. We conducted a nationwide cohort study using data from the Danish national registers (Lynge et al., 2011 Mors et al., 2011 Wallach Kildemoes et al., 2011 Schmidt et al., 2015 Bliddal et al., 2018). The aim of this study was to investigate the association of maternal migraine with any or specific psychiatric disorders in offspring, taking into account the timing of maternal migraine diagnosis and a number of other factors that may affect the association (McLaughlin et al., 2012 Skajaa et al., 2019). We hypothesised that maternal migraine could affect the fetal brain development and consequently mental health in offspring throughout the lifespan (Gandal et al., 2018). To our knowledge, no research has provided a comprehensive evaluation of the mental health outcomes of these children exposed to maternal migraine. Only one study examined maternal migraine and bipolar disorder in offspring (Sucksdorff et al., 2016). If this hypothesis holds true, we should expect that maternal migraine would be associated with a higher risk of psychiatric disorders in offspring. It was suggested that maternal migraine may affect offspring psychiatric disorders via altered intrauterine environment in the central nervous system (Burch, 2020). Children of mothers with migraine had more psychological and behavioural problems that were assessed through questionnaires in several previous studies (Evans et al., 2005 Kaasbøll et al., 2012 Güngen et al., 2017). There is growing concern of the long-term mental health problems in the children born to mothers with migraine (Evans et al., 2005 Kaasbøll et al., 2012 Güngen et al., 2017). Women are three times more likely to experience migraine than men, and are predominantly affected during their childbearing years (Burch et al., 2018). Migraine is the most common chronic neurovascular disorder, ranking the second leading cause of years of life with disability (Vos et al., 2017 Dodick, 2018). Research on prenatal origins of those diseases would provide important knowledge for developing more effective prevention strategies, which may open a new era of disease control for mental health problems (O'Donnell and Meaney, 2017). Even though genetic components might be significant contributors to many psychiatric disease, increasing empirical evidence have shown that adverse early-life environment, starting in utero or even before, may increase the lifetime risk of mental health problems (Tegethoff et al., 2011). The aetiology of psychiatric disorders involves interaction of genetic, environment and lifestyle behaviours (Kraemer et al., 2001). Psychiatric disorders affect one in five people (Charlson et al., 2019).